United States securities and exchange commission logo

                          July 7, 2023

       Mark Guerin
       Chief Operating Officer & Chief Financial Officer
       Onconova Therapeutics, Inc.
       12 Penns Trail
       Newtown, PA 18940

                                                        Re: Onconova
Therapeutics, Inc.
Statement on Form S-3
                                                            Filed June 30, 2023
                                                            File No. 333-273081

       Dear Mark Guerin:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Lauren
Hamill at 303-844-1008 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Maddy Anand