0001558370-21-016043 | 10-Q | XBRL Viewer | Onconova Therapeutics INC

Print Document View Excel Document

Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 30, 2021	Nov. 01, 2021
Document and Entity Information
Entity Registrant Name	Onconova Therapeutics, Inc.
Entity Central Index Key	0001130598
Document Type	10-Q
Document Period End Date	Sep. 30, 2021
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Quarterly Report	true
Document Transition Report	false
Entity Current Reporting Status	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Interactive Data Current	Yes
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		20,890,563
Document Fiscal Year Focus	2021
Document Fiscal Period Focus	Q3
Title of 12(b) Security	Common Stock, par value $.01 per share
Trading Symbol	ONTX
Security Exchange Name	NASDAQ
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	22-3627252
Entity File Number	001-36020
Entity Address, Address Line One	12 Penns Trail
Entity Address, City or Town	Newtown
Entity Address, State or Province	PA
Entity Address, Postal Zip Code	18940
City Area Code	267
Local Phone Number	759-3680

Condensed Consolidated Balance Sheets - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 59,378,000	$ 19,025,000
Receivables	29,000	37,000
Prepaid expenses and other current assets	529,000	722,000
Total current assets	59,936,000	19,784,000
Property and equipment, net	42,000	52,000
Other non-current assets	12,000	150,000
Total assets	59,990,000	19,986,000
Current liabilities:
Accounts payable	4,050,000	4,833,000
Accrued expenses and other current liabilities	2,749,000	4,962,000
Deferred revenue	226,000	226,000
Total current liabilities	7,025,000	10,021,000
Warrant liability		321,000
Deferred revenue, non-current	3,299,000	3,469,000
Total liabilities	10,324,000	13,811,000
Commitments and contingencies
Stockholders' equity:
Preferred stock, $0.01 par value, 5,000,000 authorized at September 30, 2021 and December 31, 2020, none issued and outstanding at September 30, 2021 and December 31, 2020
Common stock, $0.01 par value, 125,000,000 and 250,000,000 authorized at September 30, 2021 and December 31, 2020, 20,890,563 and 12,396,219 shares issued and outstanding at September 30, 2021 and December 31, 2020	209,000	124,000
Additional paid in capital	490,418,000	434,593,000
Accumulated deficit	(440,955,000)	(428,556,000)
Accumulated other comprehensive income	(6,000)	14,000
Total stockholders' equity	49,666,000	6,175,000
Total liabilities and stockholders' equity	$ 59,990,000	$ 19,986,000

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2021	Dec. 31, 2020
Condensed Consolidated Balance Sheets
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	125,000,000	250,000,000
Common stock, shares issued	20,890,563	12,396,219
Common stock, shares outstanding	20,890,563	12,396,219

Condensed Consolidated Statements of Operations - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Condensed Consolidated Statements of Operations
Revenue	$ 57,000	$ 66,000	$ 170,000	$ 174,000
Operating expenses:
General and administrative	2,284,000	2,147,000	7,351,000	6,548,000
Research and development	1,763,000	4,193,000	5,552,000	12,364,000
Total operating expenses	4,047,000	6,340,000	12,903,000	18,912,000
Loss from operations	(3,990,000)	(6,274,000)	(12,733,000)	(18,738,000)
Change in fair value of warrant liability	530,000	56,000	321,000	(63,000)
Other income (loss), net	7,000	(23,000)	13,000	73,000
Net loss	$ (3,453,000)	$ (6,241,000)	$ (12,399,000)	$ (18,728,000)
Net loss per share, basic and diluted (in dollars per share)	$ (0.22)	$ (0.52)	$ (0.80)	$ (1.65)
Basic and diluted weighted average shares outstanding (in shares)	15,979,180	12,058,508	15,463,720	11,353,169

Condensed Consolidated Statements of Comprehensive Loss - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Condensed Consolidated Statements of Comprehensive Loss
Net loss	$ (3,453,000)	$ (6,241,000)	$ (12,399,000)	$ (18,728,000)
Other comprehensive (loss) income, net of tax:
Foreign currency translation adjustments, net	(8,000)	15,000	(20,000)	16,000
Other comprehensive (loss) income, net of tax	(8,000)	15,000	(20,000)	16,000
Comprehensive loss	$ (3,461,000)	$ (6,226,000)	$ (12,419,000)	$ (18,712,000)

- Definition

Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income. Excludes changes in equity resulting from investments by owners and distributions to owners.

+ References + Details

- Definition

Amount after tax and reclassification adjustments of other comprehensive income (loss).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1A
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121641772&loc=SL7669619-108580

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=109259400&loc=d3e21463-112644

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 830
-SubTopic 30
-Section 45
-Paragraph 17
-URI http://asc.fasb.org/extlink&oid=118261656&loc=d3e32136-110900

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(21))
-URI http://asc.fasb.org/extlink&oid=120395209&loc=SL114868664-224227

Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 55
-Paragraph 15
-URI http://asc.fasb.org/extlink&oid=121640130&loc=d3e1436-108581

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 830
-SubTopic 30
-Section 45
-Paragraph 20
-URI http://asc.fasb.org/extlink&oid=118261656&loc=d3e32211-110900

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 830
-SubTopic 30
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6450520&loc=d3e32583-110901

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1B
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121641772&loc=SL7669625-108580

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(23))
-URI http://asc.fasb.org/extlink&oid=120399700&loc=SL114874048-224260

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 220
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(19))
-URI http://asc.fasb.org/extlink&oid=120400993&loc=SL114874131-224263

+ Details

- Definition

The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(g)(1)(ii))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1A
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121641772&loc=SL7669619-108580

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 205
-SubTopic 20
-Section 50
-Paragraph 7
-URI http://asc.fasb.org/extlink&oid=109222650&loc=SL51721683-107760

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)(2)
-URI http://asc.fasb.org/extlink&oid=109234566&loc=d3e22499-107794

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 28
-Subparagraph (f)
-URI http://asc.fasb.org/extlink&oid=75031198&loc=d3e14064-108612

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 50
-Paragraph 1A
-Subparagraph (a)(1)
-URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 235
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-05(b)(2))
-URI http://asc.fasb.org/extlink&oid=120399901&loc=d3e537907-122884

Reference 8: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 31
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8924-108599

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section 45
-Paragraph 1B
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121641772&loc=SL7669625-108580

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=109234566&loc=d3e22663-107794

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8736-108599

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 50
-Paragraph 1A
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684

Reference 14: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 55
-Paragraph 4J
-URI http://asc.fasb.org/extlink&oid=120409616&loc=SL4591551-111686

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8906-108599

Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3000-108585

Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 45
-Paragraph 19
-URI http://asc.fasb.org/extlink&oid=108774443&loc=SL4569616-111683

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 323
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (f)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 20: http://www.xbrl.org/2003/role/exampleRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 810
-SubTopic 10
-Section 55
-Paragraph 4K
-URI http://asc.fasb.org/extlink&oid=120409616&loc=SL4591552-111686

Reference 21: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 250
-SubTopic 10
-Section 50
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=109234566&loc=d3e22658-107794

+ Details

Consolidated Statement of Stockholders' Equity (Deficit) - USD ($)	Common Stock	Additional Paid in Capital	Accumulated deficit	Accumulated other comprehensive (loss) income	Total
Balance at Dec. 31, 2019	$ 74,000	$ 414,917,000	$ (403,399,000)	$ (18,000)	$ 11,574,000
Balance (in shares) at Dec. 31, 2019	7,411,157
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(18,728,000)		(18,728,000)
Other comprehensive income (loss)				16,000	16,000
Stock-based compensation		275,000			275,000
Issuance of common stock, net	$ 18,000	9,044,000			9,062,000
Issuance of common stock, net (in shares)	1,844,168
Issuance of common stock upon exercise of warrants	$ 30,000	9,985,000			10,015,000
Issuance of common stock upon exercise of warrants (in shares)	2,964,560
Issuance of common stock, pre-funded warrants and warrants, net	$ 1,000				1,000
Issuance of common stock, pre-funded warrants and warrants, net (in shares)	83,334
Balance at Sep. 30, 2020	$ 123,000	434,221,000	(422,127,000)	(2,000)	12,215,000
Balance (in shares) at Sep. 30, 2020	12,303,219
Balance at Jun. 30, 2020	$ 116,000	431,420,000	(415,886,000)	(17,000)	15,633,000
Balance (in shares) at Jun. 30, 2020	11,611,830
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(6,241,000)		(6,241,000)
Other comprehensive income (loss)				15,000	15,000
Stock-based compensation		90,000			90,000
Issuance of common stock upon exercise of warrants	$ 7,000	2,711,000			2,718,000
Issuance of common stock upon exercise of warrants (in shares)	691,389
Balance at Sep. 30, 2020	$ 123,000	434,221,000	(422,127,000)	(2,000)	12,215,000
Balance (in shares) at Sep. 30, 2020	12,303,219
Balance at Dec. 31, 2020	$ 124,000	434,593,000	(428,556,000)	14,000	$ 6,175,000
Balance (in shares) at Dec. 31, 2020	12,396,219				12,396,219
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(12,399,000)		$ (12,399,000)
Other comprehensive income (loss)				(20,000)	(20,000)
Exercise of stock options		24,000			24,000
Exercise of stock options (in shares)	4,642
Stock-based compensation		315,000			315,000
Shares issued in connection with reverse stock split	104
Issuance of common stock, net	$ 83,000	55,008,000			55,091,000
Issuance of common stock, net (in shares)	8,329,598
Issuance of common stock upon exercise of warrants	$ 2,000	478,000			480,000
Issuance of common stock upon exercise of warrants (in shares)	160,000
Balance at Sep. 30, 2021	$ 209,000	490,418,000	(440,955,000)	(6,000)	$ 49,666,000
Balance (in shares) at Sep. 30, 2021	20,890,563				20,890,563
Balance at Jun. 30, 2021	$ 158,000	470,335,000	(437,502,000)	2,000	$ 32,993,000
Balance (in shares) at Jun. 30, 2021	15,781,040
Increase (Decrease) in Stockholders' Equity (Deficit)
Net loss			(3,453,000)		(3,453,000)
Other comprehensive income (loss)				(8,000)	(8,000)
Stock-based compensation		190,000			190,000
Issuance of common stock, net	$ 51,000	19,893,000			19,944,000
Issuance of common stock, net (in shares)	5,109,523
Balance at Sep. 30, 2021	$ 209,000	$ 490,418,000	$ (440,955,000)	$ (6,000)	$ 49,666,000
Balance (in shares) at Sep. 30, 2021	20,890,563				20,890,563

Condensed Consolidated Statements of Cash Flows - USD ($)	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
Operating activities:
Net loss	$ (12,399,000)	$ (18,728,000)
Adjustment to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	10,000	9,000
Change in fair value of warrant liabilities	(321,000)	63,000
Stock compensation expense	315,000	275,000
Changes in assets and liabilities:
Receivables	8,000	52,000
Prepaid expenses and other current assets	193,000	(107,000)
Other assets	138,000
Accounts payable	(783,000)	1,454,000
Accrued expenses and other current liabilities	(2,213,000)	(456,000)
Deferred revenue	(170,000)	(169,000)
Net cash used in operating activities	(15,222,000)	(17,607,000)
Investing activities:
Payments for purchase of property and equipment		(15,000)
Net cash used in investing activities		(15,000)
Financing activities:
Proceeds from the sale of common stock and warrants, net of costs	55,091,000	9,062,000
Proceeds from the exercise of warrants	480,000	10,016,000
Proceeds from the exercise of stock options	24,000
Net cash provided by financing activities	55,595,000	19,078,000
Effect of foreign currency translation on cash	(20,000)	16,000
Net increase in cash and cash equivalents	40,353,000	1,472,000
Cash and cash equivalents at beginning of period	19,025,000	22,726,000
Cash and cash equivalents at end of period	$ 59,378,000	$ 24,198,000

Nature of Business

9 Months Ended

Sep. 30, 2021

Nature of Business

Nature of Business

1. Nature of Business

The Company

Onconova Therapeutics, Inc. (the “Company”) was incorporated in the State of Delaware on December 22, 1998 and commenced operations on January 1, 1999. The Company’s headquarters are located in Newtown, Pennsylvania. The Company is a clinical-stage biopharmaceutical company focused on discovering and developing novel products for patients with cancer. The Company has proprietary targeted anti-cancer agents designed to disrupt specific cellular pathways that are important for cancer cell proliferation. The Company believes that the product candidates in its pipeline have the potential to be efficacious in a variety of cancers with unmet medical need. The Company has the following two clinical-stage programs: 1. narazaciclib (ON 123300), a multi-kinase inhibitor in solid tumors; and 2. oral rigosertib alone or in combination with PD-1 inhibitors for treatment of KRAS-mutated solid tumors. During 2012, Onconova Europe GmbH was established as a wholly owned subsidiary of the Company for the purpose of further developing business in Europe.

The Company has entered into several license and collaboration agreements. In 2011, the Company entered into a license agreement, as subsequently amended, with SymBio Pharmaceuticals Limited (“SymBio”), which grants SymBio certain rights to commercialize rigosertib in Japan and Korea. In December 2017, the Company entered into a license and collaboration agreement with HanX Biopharmaceuticals, Inc. (“HanX”) for the further development, registration and commercialization of narazaciclib in greater China. Narazaciclib is a preclinical compound which the Company believes has the potential to overcome the limitations of current generation CDK 4/6 inhibitors. Under the terms of the agreement, the Company received an upfront payment, and will receive regulatory and commercial milestone payments, as well as royalties on Chinese sales. The key feature of the collaboration is that HanX provides all funding required for Chinese IND enabling studies performed for Chinese Food and Drug Administration IND approval, which was received in January 2020. The Company and HanX also intended for these studies to comply with the FDA standards for IND approval. Accordingly, such studies were used by the Company for an IND filing with the US FDA in November 2020. The FDA Study May Proceed letter was issued in December 2020. The Company maintains global rights outside of China. On March 2, 2018, the Company entered into a License, Development and Commercialization Agreement (the “Pint License Agreement”) with Pint International SA (which, together with its affiliate Pint Pharma GmbH, are collectively referred to as “Pint”). Under the terms of the agreement, the Company granted Pint an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and commercialize any pharmaceutical product containing rigosertib in all uses of rigosertib in certain Latin American countries. In May 2019, the Company entered into a License and Collaboration Agreement (the “HanX License Agreement”) with HanX. Under the terms of the HanX License Agreement, the Company granted HanX an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and commercialize any pharmaceutical product (the “HanX Product”) containing rigosertib in all uses of rigosertib or the HanX Product in human therapeutic uses in the People’s Republic of China, Hong Kong, Macau and Taiwan (the “HanX Territory”). In connection with the HanX License Agreement, the Company also entered into a Securities Purchase Agreement with each of HanX and Abundant New Investments Ltd. (“Abundant”), an affiliate of HanX (each, a “Securities Purchase Agreement” and together, the “Securities Purchase Agreements”). HanX did not fulfill its obligations under the HanX License Agreement and in January 2020, in accordance with the terms of the HanX License Agreement, the HanX License Agreement was deemed to be void ab initio. Upon this termination, the rights to HanX Product in the HanX Territory reverted to the Company in accordance with the terms of the HanX License Agreement. In addition, the Securities Purchase Agreements terminated automatically effective upon the termination of the HanX License Agreement in accordance with the Securities Purchase Agreements. In November 2019, the Company entered into a Distribution, License and Supply Agreement (the “Knight License Agreement”) with Knight Therapeutics Inc. (“Knight”). Under the terms of the Knight License Agreement, the Company granted Knight (i) a non-exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and manufacture any product (the “Knight Licensed Product”) containing rigosertib for Canada (and Israel, should Knight exercise its option as set forth in the Knight License Agreement) (the “Knight Territory”) and in human uses (the

“Field”), and (ii) an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know-how, to commercialize the Knight Licensed Product in the Knight Territory and in the Field. Knight has also agreed to obtain from the Company all of its requirements of the Knight Licensed Products for the Knight Territory, and the Company has agreed to supply Knight with all of its requirements of the Knight Licensed Products. In December 2019, the Company entered into a Distribution, License and Supply Agreement (the “STA License Agreement”) with Specialised Therapeutics Asia Pte. Ltd. (“STA”). Under the terms of the STA License Agreement, the Company granted STA (i) a non-exclusive, royalty -bearing license, with the right to sublicense, under certain Company patent rights and know-how, to develop and manufacture any product (the “STA Licensed Product”) containing rigosertib for Australia and New Zealand (the “STA Territory”) and in human uses (the “Field”), and (ii) an exclusive, royalty-bearing license, with the right to sublicense, under certain Company patent rights and know- how, to commercialize the STA Licensed Product in the STA Territory and in the Field. STA has also agreed to obtain from the Company all of its requirements of the STA Licensed Products for the STA Territory, and the Company has agreed to supply STA with all of its requirements of the STA Licensed Products.

On May 20, 2021, the Company amended its certificate of incorporation to effect a one-for-fifteen reverse stock split of its common stock. All common stock, equity, share and per share amounts in the financial statements and notes have been retroactively adjusted to reflect this one-for-fifteen reverse stock split.

On May 20, 2021, the Company amended its certificate of incorporation to decrease the number of authorized shares of common stock par value $0.01 per share from 250,000,000 to 125,000,000.

Liquidity

The Company has incurred recurring operating losses since inception. For the nine months ended September 30, 2021, the Company incurred a net loss of $12,399,000 and as of September 30, 2021 the Company had generated an accumulated deficit of $440,955,000. The Company anticipates operating losses to continue for the foreseeable future due to, among other things, costs related to research, development of its product candidates and its preclinical programs, strategic alliances and its administrative organization. At September 30, 2021, the Company had cash and cash equivalents of $59,378,000. The Company will require substantial additional financing to fund its ongoing clinical trials and operations, and to continue to execute its strategy.

On January 11, 2021, the Company closed on an offering of common stock. The Company issued 1,303,408 shares of common stock and net proceeds were approximately $8.5 million. On February 16, 2021, the Company closed on an offering of common stock. The Company issued 1,916,667 shares of common stock and net proceeds were approximately $26.7 million. On September 28, 2021, the Company closed on an offering of common stock. The Company issued 5,000,000 shares of common stock and net proceeds were approximately $19.5 million.

On August 20, 2021, the Company entered into an at-the-market equity distribution agreement for the sale of up to $25.0 million of common stock. Through September 30, 2021, the Company sold 109,523 shares under the agreement at a weighted average price of $5.32 per share. Net proceeds after commissions and offering expenses were approximately $0.5 million.

Following the unsuccessful conclusion of the INSPIRE trial, the Company has taken steps to reduce its cash expenditures. From September 2020 to December 2020, the Company implemented a workforce reduction of employees in research and development who were primarily focused on preparing the NDA for the use of rigosertib in higher risk MDS. In total, 10 employees were terminated, representing approximately 43% of the Company’s workforce. A severance related charge of approximately $1,207,000, which includes a non-cash charge of approximately $29,000 related to the accelerated vesting of outstanding stock options, was recorded in the year ended December 31, 2020. The accrued severance balance was included in accrued expenses and other liabilities on the balance sheet. It was paid in

periodic amounts through September 2021. On October 30, 2020, the Company notified its landlord of its intention to not renew its office space lease. The lease expired in February 2021 and was modified to a month-to-month lease for a portion of the space. The lease terminated in June 2021 and the Company has relocated to temporary office space with all employees working remotely.

The Company has and may continue to delay, scale-back, or eliminate certain of its research and development activities and other aspects of its operations until such time as the Company is successful in securing additional funding. The Company is exploring various dilutive and non-dilutive sources of funding, including equity financings, strategic alliances, business development and other sources. The future success of the Company is dependent upon its ability to obtain additional funding. There can be no assurance, however, that the Company will be successful in obtaining such funding in sufficient amounts, on terms acceptable to the Company, or at all. The Company believes that its cash and cash equivalents will be sufficient to fund its ongoing trials and business operations for more than twelve months from the date of this filing.

COVID-19

While the Company is not aware of a material impact from the novel coronavirus disease (“COVID-19”) pandemic through September 30, 2021, the full extent to which COVID-19 will directly or indirectly impact the Company’s business, results of operations and financial condition, including manufacturing, clinical trials and research and development costs, depends on future developments that are highly uncertain at this time.

Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2021

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

Basis of Presentation

The condensed consolidated financial statements are prepared in conformity with accounting principles generally accepted in the United States (“GAAP”) for interim financial information. Certain information and footnotes normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”). The financial statements include the consolidated accounts of the Company and its wholly-owned subsidiary, Onconova Europe GmbH. All significant intercompany transactions have been eliminated.

Unaudited Interim Financial Information

The accompanying condensed consolidated balance sheet as of September 30, 2021, the condensed consolidated statements of operations and comprehensive loss for the three and nine months ended September 30, 2021 and 2020, the consolidated statements of stockholders’ equity (deficit) for the three and nine months ended September 30, 2021 and 2020 and the condensed consolidated statements of cash flows for the nine months ended September 30, 2021 and 2020 are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2021, the results of its operations for the three and nine months ended September 30, 2021 and 2020, and its cash flows for the nine months ended September 30, 2021 and 2020. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2021 and 2020 are unaudited. The results for the three and nine months ended September 30, 2021 are not necessarily indicative of results to be expected for the year ending December 31, 2021, any other interim periods, or any future year or period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the notes thereto for the year ended December 31, 2020 included in the Company’s annual report on Form 10-K filed with the SEC on March 18, 2021.

All common stock, equity, share and per share amounts in the financial statements and notes have been retroactively adjusted to reflect a one-for-fifteen reverse stock split which was effective May 20, 2021.

Segment Information

Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one segment, which is the identification and development of oncology therapeutics.

Significant Accounting Policies

The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2020 included in the Company’s annual report on Form 10-K filed with the SEC on March 18, 2021. Since the date of such financial statements, there have been no changes to the Company’s significant accounting policies.

Fair Value Measurements

The carrying amounts reported in the accompanying consolidated financial statements for cash and cash equivalents, accounts payable, and accrued liabilities approximate their respective fair values because of the short-term nature of these accounts. The fair value of the warrant liability is discussed in Note 7, “Fair Value Measurements.”

Recent Accounting Pronouncements

In June 2016, the FASB issued new guidance on the accounting for credit losses on financial instruments. The guidance was amended in November 2019. The new guidance introduces an expected loss model for estimating credit losses, replacing the incurred loss model. The new guidance also changes the impairment model for available-for-sale debt securities, requiring the use of an allowance to record estimated credit losses (and subsequent recoveries). The guidance is effective for the Company in fiscal years beginning after December 15, 2022, and interim periods within those years, with early adoption permitted. The Company is evaluating the impact of the adoption of the standard on its consolidated financial statements.

Revenue

9 Months Ended

Sep. 30, 2021

Revenue.

Revenue

3. Revenue

The Company’s revenue during the three and nine months ended September 30, 2021 and 2020 was from its license and collaboration agreement with SymBio.


	Three Months Ended September 30,				Nine Months Ended September 30,
	2021		2020		2021		2020
Symbio
Upfront license fee recognition over time	$	57,000	$	56,000	$	170,000	$	169,000
Supplies		—		10,000		—		5,000

	$	57,000	$	66,000	$	170,000	$	174,000

Deferred revenue is as follows:


	Symbio
	Upfront Payment
Deferred balance at December 31, 2020	$	3,695,000
Recognition to revenue		170,000

Deferred balance at September 30, 2021	$	3,525,000

- Definition

The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-URI http://asc.fasb.org/topic&trid=49130388

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130551-203045

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 13
-Subparagraph (b)(2)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130556-203045

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 12
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130554-203045

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130550-203045

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 12
-Subparagraph (e)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130554-203045

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 12
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130554-203045

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 12
-Subparagraph (d)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130554-203045

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 15
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130558-203045

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 12
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130554-203045

+ Details

Net Loss Per Share of Common Stock

9 Months Ended

Sep. 30, 2021

Net Loss Per Share of Common Stock

Net Loss Per Share of Common Stock

4. Net Loss Per Share of Common Stock

The following potentially dilutive securities outstanding at September 30, 2021 and 2020 have been excluded from the computation of diluted weighted average shares outstanding, as they would be antidilutive (reflects the number of common shares as if the dilutive securities had been converted to common stock):


	September 30,
	2021	2020
Warrants	496,586	766,091
Stock options	438,006	66,933
	934,592	833,024

Warrants

9 Months Ended

Sep. 30, 2021

Warrants

Warrants

5. Warrants

Common Stock warrants are accounted for in accordance with applicable accounting guidance provided in ASC Topic 815, Derivatives and Hedging - Contracts in Entity’s Own Equity (ASC Topic 815), as either derivative liabilities or as equity instruments depending on the specific terms of the warrant agreement. Some of the Company’s warrants are classified as liabilities because in certain circumstances they could require cash settlement.

Warrants outstanding and warrant activity (reflects the number of common shares as if the warrants were converted to common stock) for the nine months ended September 30, 2021 is as follows:


					Balance				Balance
		Exercise		Expiration	December 31,	Warrants	Warrants	Warrants	September 30,
Description	Classification	Price		Date	2020	Issued	Exercised	Expired	2021
Non-tradable warrants	Liability	$	2,587.50	July 2021	430	—	—	(430)	—
Tradable warrants	Liability	$	1,107.00	July 2021	14,187	—	—	(14,187)	—
Non-tradable pre-funded warrants	Equity	$	2.25	July 2023	26	—	—	—	26
Non-tradable warrants	Equity	$	24.00	December 2022	26,189	—	—	—	26,189
Non-tradable warrants	Equity	$	211.50	March 2021	333	—	—	(333)	—
Non-tradable warrants	Equity	$	317.25	March 2021	556	—	—	(556)	—
Non-tradable warrants	Equity	$	116.8425	June 2021	1,000	—	—	(1,000)	—
Non-tradable pre-funded warrants	Equity	$	2.25	none	3,522	—	—	—	3,522
Non-tradable warrants	Equity	$	24.00	December 2022	120,407	—	—	—	120,407
Non-tradable pre-funded warrants	Equity	$	2.25	none	4,974	—	—	—	4,974
Non-tradable warrants	Equity	$	30.00	September 2023	7,306	—	—	—	7,306
Non-tradable warrants	Equity	$	3.00	November 2024	409,500	—	(160,000)	—	249,500
Non-tradable warrants	Equity	$	6.54375	December 2024	16,953	—	—	—	16,953
Non-tradable warrants	Equity	$	6.75450	December 2024	46,263	—	—	—	46,263
Non-tradable warrants	Equity	$	6.77850	December 2023	29,968	—	—	—	29,968
					681,614	—	(160,000)	(16,506)	505,108

Balance Sheet Detail

9 Months Ended

Sep. 30, 2021

Balance Sheet Detail

Balance Sheet Detail

6. Balance Sheet Detail

Prepaid expenses and other current assets:


	September 30,		December 31,
	2021		2020
Research and development	$	22,000	$	189,000
Manufacturing		158,000		90,000
Insurance		252,000		263,000
Other		97,000		180,000
	$	529,000	$	722,000

Property and equipment:


	September 30,		December 31,
	2021		2020
Property and equipment	$	70,000	$	70,000
Accumulated depreciation		(28,000)		(18,000)
	$	42,000	$	52,000

Accrued expenses and other current liabilities:


	September 30,		December 31,
	2021		2020
Research and development	$	1,750,000	$	2,541,000
Employee compensation		888,000		2,239,000
Professional fees		111,000		182,000
	$	2,749,000	$	4,962,000

Fair Value Measurements

9 Months Ended

Sep. 30, 2021

Fair Value Measurements

Fair Value Measurements

7. Fair Value Measurements

Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date.

The Company utilizes a valuation hierarchy for disclosure of the inputs to the valuations used to measure fair value. This hierarchy prioritizes the inputs into three broad levels as follows. Level 1 inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities. Level 2 inputs are quoted prices for similar assets and liabilities in active markets or inputs that are observable for the asset or liability, either directly or indirectly through market corroboration, for substantially the full term of the financial instrument. Level 3 inputs are unobservable inputs based on the Company’s own assumptions used to measure assets and liabilities at fair value. A financial asset or liability’s classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement.

On January 5, 2016, the Company entered into a securities purchase agreement (the “Securities Purchase Agreement”) with an institutional investor providing for the issuance and sale by the Company of 861 shares of Common Stock, at a purchase price of $2,137.50 per share and warrants to purchase up to 430 shares of Common Stock (the “Warrants”) for aggregate gross proceeds of $1,840,000. The Company classified the warrants as a liability (see Note 5). The estimated fair value using the Black-Scholes pricing model was approximately $0 at September 30, 2021 and December 31, 2020. These warrants expired in July 2021.

On July 29, 2016 the Company closed on a Rights Offering, issuing 16,000 shares of Common Stock, 14,187 Tradable Warrants and 2,918 Pre-Funded Warrants. The Tradable Warrants were exercisable for a period of five years for one share of Common Stock at an exercise price of $1,107 per share. The Company classified the Tradable Warrants as a liability (see Note 5). The Tradable Warrants were listed on the Nasdaq Capital Market. The Company determined that an active and orderly market for the Tradable Warrants developed and that the Nasdaq Capital Market price was the best indicator of fair value of the warrant liability. The quoted market price was used to determine the fair value at December 31, 2020. These warrants expired in July 2021.

The following fair value hierarchy table presents information about the Company’s financial assets and liabilities measured at fair value on a recurring basis as of September 30, 2021 and December 31, 2020:


	Fair Value Measurement as of:
	September 30, 2021								December 31, 2020
	Level 1		Level 2		Level 3		Balance		Level 1		Level 2		Level 3		Balance
Tradable warrants liability	$	—	$	—	$	—	$	—	$	321,000	$	—	$	—	$	321,000
Non-tradable warrants liability		—		—		—		—		—		—		—		—
Total	$	—	$	—	$	—	$	—	$	321,000	$	—	$	—	$	321,000

There were no transfers between levels in any of the periods reported.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Stock-Based Compensation

9 Months Ended

Sep. 30, 2021

Stock-Based Compensation

Stock-Based Compensation

8. Stock-Based Compensation

The 2018 Omnibus Incentive Compensation Plan (the “2018 Plan”) was unanimously approved by the Company’s Board of Directors on May 24, 2018 and was approved by the Company’s stockholders on June 27, 2018.

Under the 2018 Plan, the Company may grant incentive stock options, non-qualified stock options, stock awards, stock units, stock appreciation rights and other stock-based awards to employees, non-employee directors and consultants, and advisors. The maximum aggregate number of shares of the Company’s common stock that may be issued under the 2018 Plan is 26,823.

The 2018 Plan was amended and restated following unanimous approval of the Company’s Board of Directors on April 24, 2019 and was approved by the Company’s shareholders on June 17, 2019. The amended 2018 Plan (the “Amended Plan”) allowed for an additional 39,300 shares of the Company’s common stock that may be issued under the Amended Plan with respect to awards made on and after June 17, 2019.

The 2021 Incentive Compensation Plan (the “2021 Plan”) was unanimously approved by the Company’s shareholders on July 30, 2021. Upon stockholders’ approval of the 2021 Plan, no further awards will be made under the amended 2018 Plan. Under the 2021 Plan, the Company may grant incentive stock options, non-qualified stock options, stock awards, stock units, stock appreciation rights and other stock-based awards to employees, non-employee directors and consultants, and advisors. The maximum aggregate number of shares of the Company’s common stock that may be issued under the 2021 Plan is 1,300,000. At September 30, 2021, there were 917,094 shares available for future issuance.

Stock-based compensation expense includes stock options granted to employees and non-employees and has been reported in the Company’s statements of operations and comprehensive loss in either research and development expenses or general and administrative expenses depending on the function performed by the optionee. No net tax benefits related to the stock-based compensation costs have been recognized since the Company’s inception. The

Company recognized stock-based compensation expense related to stock options and restricted stock units as follows for the three and nine months ended September 30, 2021 and 2020:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2021		2020		2021		2020
General and administrative	$	153,000	$	51,000	$	270,000	$	142,000
Research and development		29,000		39,000		45,000		133,000
	$	182,000	$	90,000	$	315,000	$	275,000

A summary of stock option activity for the nine months ended September 30, 2021 is as follows:


		Options Outstanding
					Weighted
			Weighted-		Average
	Shares		Average		Remaining	Aggregate
	Available	Number	Exercise		Contractual	Intrinsic
	for Grant	of Shares	Price		Term (in years)	Value
Balance, December 31, 2020	12,339	57,939	$	368.10	8.38	$	—
Authorized	1,300,000	—
Granted	(398,575)	398,575	$	5.29	9.83		—
Exercised	—	(4,642)	$	4.65	8.47	$	21,636
Forfeitures	3,330	(13,866)	$	940.63	7.11
Balance, September 30, 2021	917,094	438,006	$	21.55	9.65	$	—
Vested or expected to vest, September 30, 2021		420,868	$	21.55	9.65	$	—
Exercisable at September 30, 2021		24,261	$	297.34	7.62	$	—

The Company accounts for all stock-based payments made to employees, non-employees and directors using an option pricing model for estimating fair value. Accordingly, stock-based compensation expense is measured based on the estimated fair value of the awards on the date of grant, net of forfeitures. Compensation expense is recognized for the portion that is ultimately expected to vest over the period during which the recipient renders the required services to the Company using the straight-line single option method.

The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes model requires the Company to make certain estimates and assumptions, assumptions related to the expected price volatility of the Common Stock, the period during which the options will be outstanding, the rate of return on risk-free investments and the expected dividend yield for the Company’s stock.

As of September 30, 2021, there was $1,897,000 of unrecognized compensation expense related to the unvested stock options which is expected to be recognized over a weighted-average period of approximately 2.24 years.

The weighted-average assumptions underlying the Black-Scholes calculation of grant date fair value include the following:


	Nine months ended September 30,
	2021			2020
Risk-free interest rate		0.89	%		0.44	%
Expected volatility		133.83	%		106.38	%
Expected term		5.93	years		6.00	years
Expected dividend yield		0	%		0	%
Weighted average grant date fair value	$	4.59		$	3.75

The weighted-average valuation assumptions were determined as follows:

●

Risk-free interest rate: The Company based the risk-free interest rate on the interest rate payable on U.S. Treasury securities in effect at the time of grant for a period that is commensurate with the assumed expected option term.

●

Expected term of options: Due to its lack of sufficient historical data, the Company estimates the expected life of its employee stock options using the “simplified” method, as prescribed in Staff Accounting Bulletin (SAB) No. 107, whereby the expected life equals the arithmetic average of the vesting term and the original contractual term of the option.

●

Expected stock price volatility: Expected volatility is based on the historical volatility of the Company’s Common Stock since its IPO in July 2013.

●

Expected annual dividend yield: The Company has never paid, and does not expect to pay, dividends in the foreseeable future. Accordingly, the Company assumed an expected dividend yield of 0.0%.

●

Estimated forfeiture rate: The Company’s estimated annual forfeiture rate on stock option grants was 4.14% in 2021 and 2020, based on the historical forfeiture experience.

On August 2, 2021, the compensation committee of the board of directors approved restricted stock unit grants to the Company’s employees (“2021 RSU”). An aggregate of 104,700 service-based RSUs were issued at a grant date fair value of $5.19. The 2021 RSU awards will be settled in stock, vest 33% on each of the the first and second anniversary of the date of grant, and vest 34% on the third anniversary of the date of grant. The 2021 RSU awards were granted under the 2021 Plan. There were no vesting events, expirations, forfeitures, or cancelations of the 2021 RSUs during the period. At September 30, 2021, the unrecognized compensation cost related to unvested service-based RSUs was $513,000, which will be recognized over the remaining service period. During the nine months ended September 30, 2021, the Company recognized $30,000 of stock-based compensation expense related to the 2021 RSUs, which is included in additional paid-in capital.

Grants of PSUs and SARs

On July 9, 2020, the compensation committee of the board of directors and the board approved a cash bonus program of cash-settled stock appreciation right (“2020 SAR”) awards and cash-settled performance stock unit (“2020 PSU”) awards to the Company’s employees. An aggregate of 2020 SAR awards with respect to 256,713 shares of common stock and 2020 PSU awards with respect to 124,220 shares of common stock were granted to the Company’s employees. The 2020 SAR awards will be settled in cash, vest 33% on the first anniversary of the date of grant, and the remaining 67% monthly over the next 24 months, have a per-share base amount of $8.40, which was the closing sales price of a share of the Company’s common stock on the grant date, and are in all cases subject to the terms and conditions of the Company’s form of SAR award agreement. The 2020 SAR awards are cash-settled and were granted outside of the 2018 Plan and the 2021 Plan.

The 2020 PSU awards vest 50% upon the submission of a new drug application (“NDA”) to the U.S. FDA for rigosertib in higher-risk myelodysplastic syndromes (“HR-MDS”) and 50% upon U.S. FDA approval of rigosertib for HR-MDS. The 2020 PSU awards have a maximum value of $21.60 per share. The maximum price per share is the per-share value based on the Company’s market capitalization at $250 million and the Company’s outstanding shares of common stock, which was 11,611,829 shares on July 9, 2020. In all cases, the 2020 PSU awards are subject to the terms and conditions of the Company’s form of PSU award agreement. The 2020 PSU awards are cash-settled and were granted outside of the 2018 Plan and the 2021 Plan.

In addition, on July 9, 2020, based on the recommendation of the compensation committee, the board approved a change in the non-employee director compensation policy that would provide for an annual SAR award (“2020 Director SAR”) with respect to 8,333 shares of common stock for each of the Company’s non-employee directors. No other changes to the non-employee director compensation policy were approved and, on July 9, 2020, the Board approved the initial 8,333 2020 Director SAR award to each of the non-employee directors for an aggregate total of 58,333 2020 Directors SAR awards granted. The 2020 Director SAR awards vest on the first anniversary of grant subject to the director’s continued service and will be settled in cash, have a per-share base amount of $8.40, and are in all cases subject to the terms and conditions of the Company’s form of 2020 Director SAR award agreement.

Each SAR subject to a 2020 SAR award represents the right to a cash payment equal to the excess, if any, of (i) the fair market value of each underlying share of the Company’s common stock, determined on the date of exercise of the SAR minus (ii) the base amount. Pursuant to the terms of the SAR awards, in no event may the cash payment for each SAR exceed $13.20, which is the maximum price per share of $21.60, minus the base amount of $8.40, subject to adjustment in accordance with the terms of the Stock Appreciation Right Award Agreement. The maximum price per share is the per-share value based on the Company’s market capitalization at $250 million and the Company’s outstanding shares of common stock, which was 11,611,829 shares on July 9, 2020.

On February 17, 2021, the compensation committee of the board of directors and the board approved a cash bonus program of cash-settled stock appreciation right (“2021 SAR”) awards and cash-settled performance stock unit (“2021 PSU”) awards to the Company’s employees. An aggregate of 2021 SAR awards with respect to 100,000 shares of common stock and 2021 PSU awards with respect to 100,000 shares of common stock were granted to the Company’s employees. The 2021 SAR awards will be settled in cash, vest 33% on the first anniversary of the date of grant, and the remaining 67% monthly over the next 24 months, have a per-share base amount of $22.65, which was the closing sales price of a share of the Company’s common stock on the grant date, and are in all cases subject to the terms and conditions of the Company’s form of SAR award agreement. Each SAR subject to a 2021 SAR award represents the right to a cash payment equal to the excess, if any, of (i) the fair market value of each underlying share of the Company’s common stock, determined on the date of exercise of the 2021 SAR minus (ii) the base amount. Pursuant to the terms of the 2021 SAR awards, in no event may the cash payment for each SAR exceed $15.45, which is the maximum price per share of $38.10, minus the base amount of $22.65, subject to adjustment in accordance with the terms of the Stock Appreciation Right Award Agreement. The maximum price per share is the per-share value based on the Company’s market capitalization at $600 million and the Company’s outstanding shares of common stock, which was 15,767,492 shares on February 17, 2021. The 2021 SAR awards are cash-settled and were granted outside of the 2018 Plan and the 2021 Plan.

The 2021 PSU awards vest 20% upon the initiation of a new clinical program with an in-licensed compound, 20% for reaching the recommended Phase 2 dose for any compound, 20% for the first patient enrolled in the expansion cohort of the Phase 1 ON123300 clinical trial, 20% for the first patient enrolled in a registrational study for any compound, and 20% for the topline data of a registrational study for any compound. The 2021 PSU awards have a maximum value of $38.10 per share. The maximum price per share is the per-share value based on the Company’s approximate market capitalization at $600 million and the Company’s outstanding shares of common stock, which was 15,767,492 shares on February 17, 2021. In all cases, the 2021 PSU awards are subject to the terms and conditions of

the Company’s form of PSU award agreement. The 2021 PSU awards are cash-settled and were granted outside of the 2018 Plan and the 2021 Plan.

The fair value of the 2021 SARs granted has been estimated using the Black-Scholes option-pricing model with the following weighted-average assumptions:


	Nine months ended
	September 30, 2021
Risk-free interest rate		0.95	%
Expected volatility		129.79	%
Expected term		6.5 years
Expected dividend yield		0	%
Weighted average grant date fair value	$	0.62

During the nine months ended September 30, 2021, the Company recognized $528,000 of compensation expense related to the SARs and PSUs. Included in compensation expense related to SARs is $442,000 of expense resulting from the exercise of 2020 SARs during February 2021. As of September 30, 2021, the SARs and PSUs liability was $86,000 and is included in accrued expenses. As of September 30, 2021, there was $28,000 of unrecognized compensation cost related to the 2020 SARs and PSUs and $350,000 of unrecognized compensation cost related to the 2021 SARs and PSUs.

Research Agreements

9 Months Ended

Sep. 30, 2021

Research Agreements

Research Agreements

9. Research Agreements

The Company has entered into various licensing and right-to-sublicense agreements with educational institutions for the exclusive use of patents and patent applications, as well as any patents that may develop from research being conducted by such educational institutions in the field of anticancer therapy, genes and proteins. Results from this research have been licensed to the Company pursuant to these agreements. Under one of these agreements with Temple University (“Temple”), the Company is required to make annual maintenance payments to Temple and royalty payments based upon a percentage of sales generated from any products covered by the licensed patents, with minimum specified royalty payments. As no sales had been generated through September 30, 2021 under the licensed patents, the Company has not incurred any royalty expenses related to this agreement. In addition, the Company is required to pay Temple a percentage of any sublicensing fees received by the Company.

Related-Party Transactions

9 Months Ended

Sep. 30, 2021

Related-Party Transactions

Related-Party Transactions

10. Related-Party Transactions

The Company entered into a research agreement, as subsequently amended, with the Mount Sinai School of Medicine (“Mount Sinai”), with which a former member of its board of directors and a stockholder is affiliated. The agreement expired in June 2020 and was not renewed. The board member left the Company’s board in August 2020. Mount Sinai is undertaking research on behalf of the Company on the terms set forth in the agreements. Mount Sinai, in connection with the Company, will prepare applications for patents generated from the research. Results from all projects will belong exclusively to Mount Sinai, but the Company will have an exclusive option to license any inventions. Payments to Mount Sinai under this research agreement for both the three months ended September 30, 2021 and 2020 were $0, and for the nine months ended September 30, 2021 and 2020 were $0 and $201,000, respectively. At both September 30, 2021 and December 31, 2020, the Company had $77,000 payable to Mount Sinai under this agreement.

Securities Registrations and Sales Agreements

9 Months Ended

Sep. 30, 2021

Securities Registrations and Sales Agreements

Securities Registrations and Sales Agreements

11. Securities Registrations and Sales Agreements

January 2020 Offering

On December 31, 2019, the Company entered into definitive securities purchase agreements with institutional investors for the issuance and sale in a registered direct offering of 1,844,168 shares of the Company's common stock at an offering price of $5.4225 per share.

Pursuant to the December 2019 HCW Engagement Letter, HCW agreed to serve as exclusive placement agent for the offering. In connection with the offering, the Company paid HCW an aggregate cash fee equal to 7.0% of the gross proceeds in the offering, management fee equal to 1.0% of the gross proceeds raised in the offering, $85,000 for non-accountable expenses; and $10,000 for clearing fees. The Company also issued to HCW or its designees placement agent warrant to purchase up to 92,208 shares of common stock at an exercise price of $6.7785 per share. The placement agent warrants are immediately exercisable and will expire on December 31, 2023.

The net proceeds to the Company from the offering, after deducting HCW's placement agent fees and expenses and other estimated offering expenses payable by the Company were approximately $9.0 million and were received in January 2020.

The offering was pursuant to a prospectus dated December 28, 2017, and a prospectus supplement dated as of December 31, 2019 filed in connection with a takedown from the Company's shelf registration statement on Form S-3 (File No. 333-221684). The offering closed on January 3, 2020.

January 7, 2021 Offering

On January 7, 2021, the Company entered into a purchase agreement with certain institutional and accredited investors for the sale of an aggregate of 1,303,408 shares of the Company’s common stock, at a purchase price of $6.675 per share.

Under the purchase agreement, subject to certain exceptions, the Company is prohibited from effecting or entering into an agreement to effect any “variable rate transactions” as defined in the purchase agreement for a period of five years following the closing of the offering.

In connection with the offering, pursuant to the purchase agreement we reimbursed Lincoln Park Capital Fund, LLC, as the lead investor (“Lincoln Park”), an aggregate of $100,000 for expenses incurred in connection with the offering, including any due diligence expenses and legal fees. Furthermore, pursuant to the purchase agreement, we have granted Lincoln Park certain rights to participate at fair value with other investors in up to 50% of the amount of any future offerings of common stock or securities exercisable for or convertible into common stock that the Company seeks to complete within one year after the closing of the offering, other than a firm commitment public offering.

The net proceeds to the Company from the offering, after deducting Lincoln Park’s expenses and other estimated offering expenses payable by the Company were approximately $8.5 million.

The shares sold in the offering were offered and sold by the Company directly to the investors, without a placement agent, underwriter, broker or dealer, pursuant to an effective shelf registration statement on Form S-3 (File No. 333-237844) declared effective by the SEC on May 18, 2020, and the base prospectus contained therein. The offering closed on January 11, 2021.

February 10, 2021 Offering

On February 10, 2021, the Company entered into an underwriting agreement with Guggenheim Securities, LLC, as representative of several underwriters, for the public offering of 1,666,667 shares of the Company’s common stock, at a public offering price of $15.00 per share. Under the terms of the underwriting agreement, the Company granted the underwriters an option, exercisable for 30 days, to purchase up to an additional 250,000 shares of common stock at the same price. The option was exercised prior to closing.

In connection with the offering, the Company paid the underwriters a cash fee equal to 6% of the gross proceeds in the offering and $100,000 in legal fees and expenses.

The net proceeds to the Company from the offering, including exercise of the underwriters’ option, were approximately $26.7 million, after deducting fees and estimated offering expenses payable by the Company.

The offering was made pursuant to a registration statement (No. 333-237844) on Form S-3, which was initially filed by the Company with the SEC on April 24, 2020, amended on Form S-3/A that was filed with the SEC on May 15, 2020, and was declared effective by the SEC on May 18, 2020. The offering closed on February 16, 2021.

August 20, 2021

On August 20, 2021, the Company entered into an Equity Distribution Agreement (the “Equity Distribution Agreement”) with Piper Sandler & Co. (“Piper Sandler”) under which the Company may offer and sell, from time to time at its sole discretion, shares of the Company’s common stock, with aggregate gross sales proceeds of up to $25.0 million through an “at the market” equity offering program under which Piper Sandler is the sales agent.

Under the Equity Distribution Agreement, the Company has the right to set the parameters for the sale of shares, including the number of shares to be issued, the time period during which sales are requested to be made, limitations on the number of shares that may be sold in any one trading day and any minimum price below which sales may not be made. Subject to the terms and conditions of the Equity Distribution Agreement, Piper Sandler may sell the shares by methods deemed to be an “at the market” offering as defined in Rule 415 promulgated under the Securities Act of 1933, as amended, including sales made through The Nasdaq Capital Market or any other trading market for our common stock. The Equity Distribution Agreement provides that Piper Sandler is entitled to compensation for its services equal to 3.0% of the gross proceeds of any shares of common stock sold through Piper Sandler under the Equity Distribution Agreement. The Company has no obligation to sell any shares under the Equity Distribution Agreement, and may at any time suspend solicitation and offers under the Equity Distribution Agreement. Through September 30, 2021, the Company sold 109,523 shares under the agreement at a weighted average price of $5.32 per share. Net proceeds after commissions and offering expenses were approximately $0.5 million.

The shares are issued pursuant to the Company’s shelf registration statement on Form S-3 (File No. 333-237844). The Company filed a prospectus supplement, dated August 20, 2021 with the Securities and Exchange Commission in connection with the offer and sale of the shares pursuant to the Equity Distribution Agreement.

September 23, 2021 Offering

On September 23, 2021, the Company entered into an underwriting agreement with Guggenheim Securities, LLC, as representative of several underwriters, for the public offering of 5,000,000 shares of the Company’s common stock, at a public offering price of $4.20 per share. Under the terms of the underwriting agreement, the Company granted the underwriters an option, exercisable for 30 days, to purchase up to an additional 750,000 shares of common stock at the same price. The option was not exercised.

In connection with the offering, the Company paid the underwriters a cash fee equal to 6% of the gross proceeds in the offering and $100,000 in legal fees and expenses.

The net proceeds to the Company from the offering, including exercise of the underwriters’ option, were approximately $19.5 million, after deducting fees and estimated offering expenses payable by the Company.

Subsequent Events

9 Months Ended

Sep. 30, 2021

Subsequent Events

Subsequent Events

Summary of Significant Accounting Policies (Policies)	9 Months Ended
Summary of Significant Accounting Policies (Policies)	Sep. 30, 2021
Summary of Significant Accounting Policies
Basis of Presentation	Basis of Presentation The condensed consolidated financial statements are prepared in conformity with accounting principles generally accepted in the United States (“GAAP”) for interim financial information. Certain information and footnotes normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”). The financial statements include the consolidated accounts of the Company and its wholly-owned subsidiary, Onconova Europe GmbH. All significant intercompany transactions have been eliminated.
Unaudited Interim Financial Information	Unaudited Interim Financial Information The accompanying condensed consolidated balance sheet as of September 30, 2021, the condensed consolidated statements of operations and comprehensive loss for the three and nine months ended September 30, 2021 and 2020, the consolidated statements of stockholders’ equity (deficit) for the three and nine months ended September 30, 2021 and 2020 and the condensed consolidated statements of cash flows for the nine months ended September 30, 2021 and 2020 are unaudited. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2021, the results of its operations for the three and nine months ended September 30, 2021 and 2020, and its cash flows for the nine months ended September 30, 2021 and 2020. The financial data and other information disclosed in these notes related to the three and nine months ended September 30, 2021 and 2020 are unaudited. The results for the three and nine months ended September 30, 2021 are not necessarily indicative of results to be expected for the year ending December 31, 2021, any other interim periods, or any future year or period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and the notes thereto for the year ended December 31, 2020 included in the Company’s annual report on Form 10-K filed with the SEC on March 18, 2021. All common stock, equity, share and per share amounts in the financial statements and notes have been retroactively adjusted to reflect a one-for-fifteen reverse stock split which was effective May 20, 2021.
Segment Information	Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one segment, which is the identification and development of oncology therapeutics.
Significant Accounting Policies	Significant Accounting Policies The Company’s significant accounting policies are disclosed in the audited consolidated financial statements for the year ended December 31, 2020 included in the Company’s annual report on Form 10-K filed with the SEC on March 18, 2021. Since the date of such financial statements, there have been no changes to the Company’s significant accounting policies.
Fair Value Measurements	Fair Value Measurements The carrying amounts reported in the accompanying consolidated financial statements for cash and cash equivalents, accounts payable, and accrued liabilities approximate their respective fair values because of the short-term nature of these accounts. The fair value of the warrant liability is discussed in Note 7, “Fair Value Measurements.”
Recent Accounting Pronouncements	Recent Accounting Pronouncements In June 2016, the FASB issued new guidance on the accounting for credit losses on financial instruments. The guidance was amended in November 2019. The new guidance introduces an expected loss model for estimating credit losses, replacing the incurred loss model. The new guidance also changes the impairment model for available-for-sale debt securities, requiring the use of an allowance to record estimated credit losses (and subsequent recoveries). The guidance is effective for the Company in fiscal years beginning after December 15, 2022, and interim periods within those years, with early adoption permitted. The Company is evaluating the impact of the adoption of the standard on its consolidated financial statements.

- Definition

Disclosure of accounting policy for segment reporting.

+ References + Details

Revenue (Tables)

9 Months Ended

Sep. 30, 2021

Revenue.

Schedule of recognized revenue under funding, license and collaboration agreements


	Three Months Ended September 30,				Nine Months Ended September 30,
	2021		2020		2021		2020
Symbio
Upfront license fee recognition over time	$	57,000	$	56,000	$	170,000	$	169,000
Supplies		—		10,000		—		5,000

	$	57,000	$	66,000	$	170,000	$	174,000

Schedule of deferred revenue


	Symbio
	Upfront Payment
Deferred balance at December 31, 2020	$	3,695,000
Recognition to revenue		170,000

Deferred balance at September 30, 2021	$	3,525,000

Net Loss Per Share of Common Stock (Tables)

9 Months Ended

Sep. 30, 2021

Net Loss Per Share of Common Stock

Schedule of antidilutive securities which have been excluded from the computation of diluted weighted average shares outstanding


	September 30,
	2021	2020
Warrants	496,586	766,091
Stock options	438,006	66,933
	934,592	833,024

Warrants (Tables)

9 Months Ended

Sep. 30, 2021

Warrants

Schedule of warrants outstanding and warrant activity


					Balance				Balance
		Exercise		Expiration	December 31,	Warrants	Warrants	Warrants	September 30,
Description	Classification	Price		Date	2020	Issued	Exercised	Expired	2021
Non-tradable warrants	Liability	$	2,587.50	July 2021	430	—	—	(430)	—
Tradable warrants	Liability	$	1,107.00	July 2021	14,187	—	—	(14,187)	—
Non-tradable pre-funded warrants	Equity	$	2.25	July 2023	26	—	—	—	26
Non-tradable warrants	Equity	$	24.00	December 2022	26,189	—	—	—	26,189
Non-tradable warrants	Equity	$	211.50	March 2021	333	—	—	(333)	—
Non-tradable warrants	Equity	$	317.25	March 2021	556	—	—	(556)	—
Non-tradable warrants	Equity	$	116.8425	June 2021	1,000	—	—	(1,000)	—
Non-tradable pre-funded warrants	Equity	$	2.25	none	3,522	—	—	—	3,522
Non-tradable warrants	Equity	$	24.00	December 2022	120,407	—	—	—	120,407
Non-tradable pre-funded warrants	Equity	$	2.25	none	4,974	—	—	—	4,974
Non-tradable warrants	Equity	$	30.00	September 2023	7,306	—	—	—	7,306
Non-tradable warrants	Equity	$	3.00	November 2024	409,500	—	(160,000)	—	249,500
Non-tradable warrants	Equity	$	6.54375	December 2024	16,953	—	—	—	16,953
Non-tradable warrants	Equity	$	6.75450	December 2024	46,263	—	—	—	46,263
Non-tradable warrants	Equity	$	6.77850	December 2023	29,968	—	—	—	29,968
					681,614	—	(160,000)	(16,506)	505,108

Balance Sheet Detail (Tables)

9 Months Ended

Sep. 30, 2021

Balance Sheet Detail

Schedule of prepaid expenses and other current assets


	September 30,		December 31,
	2021		2020
Research and development	$	22,000	$	189,000
Manufacturing		158,000		90,000
Insurance		252,000		263,000
Other		97,000		180,000
	$	529,000	$	722,000

Schedule of property and equipment


	September 30,		December 31,
	2021		2020
Property and equipment	$	70,000	$	70,000
Accumulated depreciation		(28,000)		(18,000)
	$	42,000	$	52,000

Schedule of accrued expenses and other current liabilities


	September 30,		December 31,
	2021		2020
Research and development	$	1,750,000	$	2,541,000
Employee compensation		888,000		2,239,000
Professional fees		111,000		182,000
	$	2,749,000	$	4,962,000

Fair Value Measurements (Tables)

9 Months Ended

Sep. 30, 2021

Fair Value Measurements

Schedule of financial assets and liabilities measured at fair value on a recurring basis


	Fair Value Measurement as of:
	September 30, 2021								December 31, 2020
	Level 1		Level 2		Level 3		Balance		Level 1		Level 2		Level 3		Balance
Tradable warrants liability	$	—	$	—	$	—	$	—	$	321,000	$	—	$	—	$	321,000
Non-tradable warrants liability		—		—		—		—		—		—		—		—
Total	$	—	$	—	$	—	$	—	$	321,000	$	—	$	—	$	321,000

Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2021

Stock-Based Compensation

Schedule of stock-based compensation expense


	Three Months Ended September 30,				Nine Months Ended September 30,
	2021		2020		2021		2020
General and administrative	$	153,000	$	51,000	$	270,000	$	142,000
Research and development		29,000		39,000		45,000		133,000
	$	182,000	$	90,000	$	315,000	$	275,000

Schedule of stock option activity


		Options Outstanding
					Weighted
			Weighted-		Average
	Shares		Average		Remaining	Aggregate
	Available	Number	Exercise		Contractual	Intrinsic
	for Grant	of Shares	Price		Term (in years)	Value
Balance, December 31, 2020	12,339	57,939	$	368.10	8.38	$	—
Authorized	1,300,000	—
Granted	(398,575)	398,575	$	5.29	9.83		—
Exercised	—	(4,642)	$	4.65	8.47	$	21,636
Forfeitures	3,330	(13,866)	$	940.63	7.11
Balance, September 30, 2021	917,094	438,006	$	21.55	9.65	$	—
Vested or expected to vest, September 30, 2021		420,868	$	21.55	9.65	$	—
Exercisable at September 30, 2021		24,261	$	297.34	7.62	$	—

Schedule of weighted-average assumptions used for estimating the fair value of the stock compensation granted


	Nine months ended September 30,
	2021			2020
Risk-free interest rate		0.89	%		0.44	%
Expected volatility		133.83	%		106.38	%
Expected term		5.93	years		6.00	years
Expected dividend yield		0	%		0	%
Weighted average grant date fair value	$	4.59		$	3.75

Nature of Business (Details)								1 Months Ended	3 Months Ended		4 Months Ended	9 Months Ended		12 Months Ended
Nature of Business (Details)	Sep. 28, 2021 USD ($) shares	Aug. 20, 2021 USD ($)	May 20, 2021 $ / shares shares	Feb. 16, 2021 USD ($) shares	Jan. 11, 2021 USD ($) shares	Jul. 29, 2016 shares	Jan. 05, 2016 USD ($) shares	Sep. 30, 2021 USD ($) Program $ / shares shares	Sep. 30, 2021 USD ($) Program $ / shares shares	Sep. 30, 2020 USD ($)	Dec. 31, 2020 USD ($) employee $ / shares shares	Sep. 30, 2021 USD ($) Program $ / shares shares	Sep. 30, 2020 USD ($)	Dec. 31, 2020 USD ($) $ / shares shares	May 19, 2021 shares	Jul. 09, 2020 shares	Dec. 31, 2019 USD ($)
Liquidity
Number of clinical programs (in programs) \| Program								2	2			2
Reverse stock split ratio			0.067
Common stock, par value (in dollars per share) \| $ / shares			$ 0.01					$ 0.01	$ 0.01		$ 0.01	$ 0.01		$ 0.01
Common stock authorized (in shares) \| shares			125,000,000					125,000,000	125,000,000		250,000,000	125,000,000		250,000,000	250,000,000
Net loss									$ (3,453,000)	$ (6,241,000)		$ (12,399,000)	$ (18,728,000)
Accumulated deficit								$ 440,955,000	440,955,000		$ 428,556,000	440,955,000		$ 428,556,000
Cash and cash equivalents								$ 59,378,000	$ 59,378,000	$ 24,198,000	$ 19,025,000	$ 59,378,000	24,198,000	$ 19,025,000			$ 22,726,000
Common stock outstanding (in shares) \| shares								20,890,563	20,890,563		12,396,219	20,890,563		12,396,219		11,611,829
Net proceeds	$ 19,500,000			$ 26,700,000	$ 8,500,000		$ 1,840,000					$ 55,091,000	9,062,000
Warrants Exercised \| shares												160,000
Proceeds from the exercise of warrants												$ 480,000	$ 10,016,000
Issuance of common stock, net (in shares) \| shares	5,000,000			1,916,667	1,303,408	16,000	861
FTE positions eliminated \| employee											10
FTE eliminated positions (as percent of workforce)											43.00%
Severance charge														$ 1,207,000
Non-cash charge, accelerated options														$ 29,000
Stock called by warrants or rights \| shares							430
Piper Sandler & Co
Liquidity
Net proceeds								$ 0.5
Issuance of common stock, net (in shares) \| shares								109,523
Weighted average price per of common share \| $ / shares								$ 5.32	$ 5.32			$ 5.32
Piper Sandler & Co \| At the Market Equity
Liquidity
Net proceeds								$ 500,000
Issuance of common stock, net (in shares) \| shares								109,523
Weighted average price per of common share \| $ / shares								$ 5.32	$ 5.32			$ 5.32
Piper Sandler & Co \| At the Market Equity \| Maximum
Liquidity
Net proceeds		$ 25,000,000.0

Summary of Significant Accounting Policies - Segment Information (Details)	May 20, 2021
Summary of Significant Accounting Policies
Reverse stock split	one-for-fifteen

Revenue (Details) - USD ($)	3 Months Ended		9 Months Ended
Revenue (Details) - USD ($)	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenue
Revenue	$ 57,000	$ 66,000	$ 170,000	$ 174,000
Deferred revenue
Balance at the beginning of the period			226,000
Balance at the end of the period	226,000		226,000
SymBio
Deferred revenue
Balance at the beginning of the period			3,695,000
Recognition to revenue			170,000
Balance at the end of the period	3,525,000		3,525,000
SymBio \| License
Revenue
Revenue	$ 57,000	56,000	$ 170,000	169,000
SymBio \| Supplies and other
Revenue
Revenue		$ 10,000		$ 5,000

- Definition

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8736-108599

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 323
-SubTopic 10
-Section 50
-Paragraph 3
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 28
-Subparagraph (f)
-URI http://asc.fasb.org/extlink&oid=75031198&loc=d3e14064-108612

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8736-108599

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 40
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9031-108599

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8906-108599

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 41
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9038-108599

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 42
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9054-108599

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(g)(1)(ii))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 235
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-05(b)(2))
-URI http://asc.fasb.org/extlink&oid=120399901&loc=d3e537907-122884

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 220
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(1))
-URI http://asc.fasb.org/extlink&oid=120395209&loc=SL114868664-224227

+ Details

Net Loss Per Share of Common Stock (Details) - shares	9 Months Ended
Net Loss Per Share of Common Stock (Details) - shares	Sep. 30, 2021	Sep. 30, 2020
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	934,592	833,024
Common Stock Warrants
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	496,586	766,091
Stock options
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares as they would be antidilutive
Potentially dilutive securities outstanding excluded from the computation of diluted weighted average shares	438,006	66,933

Warrants (Details) - $ / shares	9 Months Ended
Warrants (Details) - $ / shares	Sep. 30, 2021	Jan. 05, 2016
Warrants
Number of securities to each class of warrant (in shares)		430
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	681,614
Warrants Exercised (in shares)	(160,000)
Warrants Expired (in shares)	(16,506)
Balance at end of the period (in shares)	505,108
Non-tradable warrants with exercise price 172.50 Liability
Warrants
Warrant exercise price (in dollars per share)	$ 2,587.50
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	430
Warrants Expired (in shares)	(430)
Tradable warrants with exercise price 73.80 Liability
Warrants
Warrant exercise price (in dollars per share)	$ 1,107.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	14,187
Warrants Expired (in shares)	(14,187)
Non-tradable pre-funded warrants with exercise price 0.15 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	26
Balance at end of the period (in shares)	26
Non-tradable warrants with exercise price 1.60 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 24.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	26,189
Balance at end of the period (in shares)	26,189
Non-tradable warrants with exercise price 14.10 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 211.50
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	333
Warrants Expired (in shares)	(333)
Non-tradable warrants with exercise price 21.15 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 317.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	556
Warrants Expired (in shares)	(556)
Non-tradable warrants with exercise price 7.7895 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 116.8425
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	1,000
Warrants Expired (in shares)	(1,000)
Non-tradable pre-funded warrants with exercise Price 0.15 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	3,522
Balance at end of the period (in shares)	3,522
Non-tradable warrants with exercise price 1.600 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 24.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	120,407
Balance at end of the period (in shares)	120,407
Non-tradable pre-funded warrants with exercise Price 0.15 Equity1
Warrants
Warrant exercise price (in dollars per share)	$ 2.25
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	4,974
Balance at end of the period (in shares)	4,974
Non-tradable warrants with exercise price 2.00 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 30.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	7,306
Balance at end of the period (in shares)	7,306
Non-tradable warrants with exercise price 0.20 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 3.00
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	409,500
Warrants Exercised (in shares)	(160,000)
Balance at end of the period (in shares)	249,500
Non-tradable warrants with exercise price 0.43625 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 6.54375
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	16,953
Balance at end of the period (in shares)	16,953
Non-tradable warrants with exercise price 0.45030 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 6.75450
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	46,263
Balance at end of the period (in shares)	46,263
Non-tradable Warrants with Exercise Price 0.45190 Equity
Warrants
Warrant exercise price (in dollars per share)	$ 6.77850
Warrants outstanding and warrant activity
Balance at beginning of the period (in shares)	29,968
Balance at end of the period (in shares)	29,968

Balance Sheet Detail - Prepaid Expenses and Other Current Assets (Details) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Prepaid expenses and other current assets:
Research and development	$ 22,000	$ 189,000
Manufacturing	158,000	90,000
Insurance	252,000	263,000
Other	97,000	180,000
Prepaid expenses and other current assets	$ 529,000	$ 722,000

Balance Sheet Detail - Property and Equipment (Details) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Property and Equipment
Property and equipment	$ 70,000	$ 70,000
Accumulated depreciation	(28,000)	(18,000)
Property and equipment, net	$ 42,000	$ 52,000

Balance Sheet Detail - Accrued Expenses and Other Current Liabilities (Details) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Balance Sheet Detail
Research and development	$ 1,750,000	$ 2,541,000
Employee compensation	888,000	2,239,000
Professional fees	111,000	182,000
Accrued expenses and other current liabilities	$ 2,749,000	$ 4,962,000

Fair Value Measurements (Details) - USD ($)						9 Months Ended
Fair Value Measurements (Details) - USD ($)	Sep. 28, 2021	Feb. 16, 2021	Jan. 11, 2021	Jul. 29, 2016	Jan. 05, 2016	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020	Jul. 09, 2020
Sale of Securities
Aggregate shares issued	5,000,000	1,916,667	1,303,408	16,000	861
Price per share (in dollars per share)					$ 2,137.50				$ 21.60
Stock called by warrants or rights					430
Proceeds from Issuance of Common Stock	$ 19,500,000	$ 26,700,000	$ 8,500,000		$ 1,840,000	$ 55,091,000	$ 9,062,000
Estimated fair value using the Black-Scholes pricing model						$ 0		$ 0

Fair Value Measurements - Rights Offering (Details) - $ / shares	Sep. 28, 2021	Feb. 16, 2021	Jan. 11, 2021	Jul. 29, 2016	Jan. 05, 2016
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)	5,000,000	1,916,667	1,303,408	16,000	861
Tradable warrants liability
Subsidiary, Sale of Stock [Line Items]
Rights or warrants issued (in shares)				14,187
Shares into which each warrant can be converted (in shares)				1
Exercise price (in dollars per share)				$ 1,107
Class Of Warrant Or Right Initially Exercisable Term				five
Pre-funded warrants
Subsidiary, Sale of Stock [Line Items]
Rights or warrants issued (in shares)				2,918

Fair Value Measurements - Fair Value Hierarchy Table (Details)	Dec. 31, 2020 USD ($)
Liabilities measured at fair value
Warrant liability	$ 321,000
Recurring basis
Liabilities measured at fair value
Total	321,000
Recurring basis \| Tradable warrants liability
Liabilities measured at fair value
Warrant liability	321,000
Recurring basis \| Level 1
Liabilities measured at fair value
Total	321,000
Recurring basis \| Level 1 \| Tradable warrants liability
Liabilities measured at fair value
Warrant liability	$ 321,000

Stock-Based Compensation (Details) - USD ($) $ in Millions				9 Months Ended
Stock-Based Compensation (Details) - USD ($) $ in Millions	Feb. 17, 2021	Jul. 09, 2020	Jun. 17, 2019	Sep. 30, 2021	Dec. 31, 2020
Stock-Based Compensation
Market Capitalization	$ 600.0	$ 250.0
2018 Plan
Stock-Based Compensation
Shares authorized (in shares)				26,823
Additional shares authorized (in shares)			39,300
2021 Incentive Plan
Stock-Based Compensation
Shares authorized (in shares)				1,300,000
Stock options
Stock-Based Compensation
Additional shares authorized (in shares)				1,300,000
Common Stock available for future issuance (in shares)				917,094	12,339
Stock options \| 2021 Incentive Plan
Stock-Based Compensation
Common Stock available for future issuance (in shares)				917,094

Stock-Based Compensation - Expense (Details) - USD ($)	3 Months Ended		9 Months Ended
Stock-Based Compensation - Expense (Details) - USD ($)	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Stock-Based Compensation
Net tax benefits related to the stock-based compensation costs			$ 0
Compensation expense	$ 182,000	$ 90,000	315,000	$ 275,000
General and administrative
Stock-Based Compensation
Compensation expense	153,000	51,000	270,000	142,000
Research and development
Stock-Based Compensation
Compensation expense	$ 29,000	$ 39,000	$ 45,000	$ 133,000

Stock-Based Compensation - Activity (Details) - Stock options - USD ($)	6 Months Ended	9 Months Ended	12 Months Ended
	Jun. 30, 2021	Sep. 30, 2021	Dec. 31, 2020
Shares Available for Grant
Balance at the beginning of the period (in shares)	12,339	12,339
Authorized		1,300,000
Granted (in shares)		(398,575)
Exercised (in shares)		4,642
Forfeitures (in shares)		3,330
Balance at the end of the period (in shares)		917,094	12,339
Number of Shares
Balance at the beginning of the period (in shares)	57,939	57,939
Granted (in shares)		398,575
Exercised (in shares)		(4,642)
Forfeitures (in shares)		(13,866)
Balance at the end of the period (in shares)		438,006	57,939
Vested or expected to vest at the end of the period (in shares)		420,868
Exercisable at the end of the period (in shares)		24,261
Weighted-Average Exercise Price
Balance at the beginning of the period (in dollars per share)	$ 368.10	$ 368.10
Granted (in dollars per share)		5.29
Exercised (in dollars per share)		4.65
Forfeitures (in dollars per share)		940.63
Balance at the end of the period (in dollars per share)		21.55	$ 368.10
Vested or expected to vest at the end of the period (in dollars per share)		21.55
Exercisable at the end of the period (in dollars per share)		$ 297.34
Additional Disclosures
Weighted average remaining contractual term		9 years 7 months 24 days	8 years 4 months 17 days
Weighted average remaining contractual term of options granted		9 years 9 months 29 days
Weighted average remaining contractual term of options exercised		8 years 5 months 19 days
Weighted average remaining contractual term of options forfeitures		7 years 1 month 9 days
Weighted average remaining contractual term of options vested or expected to vest		9 years 7 months 24 days
Weighted average remaining contractual term of options exercisable		7 years 7 months 13 days
Aggregate intrinsic value of options exercised	$ 21,636

Stock-Based Compensation - Unrecognized Compensation Expense (Details)	9 Months Ended
	Sep. 30, 2021 USD ($)
Stock options
Stock-Based Compensation
Unrecognized compensation expense related to unvested stock options	$ 1,897,000
Weighted-average period for recognizing unrecognized compensation expense related to unvested stock options (in years)	2 years 2 months 26 days
SAR awards
Stock-Based Compensation
Unrecognized compensation expense related to unvested stock options	$ 528,000
2020 SAR
Stock-Based Compensation
Unrecognized compensation expense related to unvested stock options	28,000
2021 SAR
Stock-Based Compensation
Unrecognized compensation expense related to unvested stock options	$ 350,000

Stock-Based Compensation - Fair Value Assumptions (Details) - USD ($) $ / shares in Units, $ in Thousands	9 Months Ended		12 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Assumptions used
Expected term	6.5 years
Expected dividend yield (as a percent)	0.00%
SARs liability	$ 86,000
Stock options
Assumptions used
Risk-free interest rate (as a percent)	0.89%	0.44%
Expected volatility (as a percent)	133.83%	106.38%
Expected term (in years)	5 years 11 months 4 days	6 years
Expected dividend yield (as a percent)	0.00%	0.00%
Weighted average grant date fair value (in dollars per share)	$ 4.59	$ 3.75
Annualized forfeiture rate (as a percent)	4.14%		4.14%
2021 SAR
Assumptions used
Risk-free interest rate (as a percent)	0.95%
Expected volatility (as a percent)	129.79%
Expected dividend yield (as a percent)	0.00%
Weighted average grant date fair value (in dollars per share)	$ 0.62

Stock-Based Compensation - Grants of PSUs and SARs (Details) - USD ($)			3 Months Ended		9 Months Ended
	Feb. 17, 2021	Jul. 09, 2020	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020	Jan. 05, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)		$ 21.60						$ 2,137.50
Common stock outstanding (in shares)		11,611,829	20,890,563		20,890,563		12,396,219
Market capitalization	$ 600,000,000	$ 250,000,000
Compensation expense			$ 182,000	$ 90,000	$ 315,000	$ 275,000
SAR Award Agreement [member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)			$ 15.45		$ 15.45
Common stock outstanding (in shares)	15,767,492
SAR Award Agreement [member] \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)			38.10		38.10
SAR Award Agreement [member] \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)			$ 22.65		$ 22.65
2020 PSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock option grants		124,220
2021 PSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock outstanding (in shares)	15,767,492
Market capitalization	$ 600,000,000
Shares issued			100,000		100,000
2021 PSU \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)	$ 38.10
2021 PSU \| Initiation of a new clinical program with an in-licensed compound
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	20.00%
2021 PSU \| Reaching the recommended Phase 2 dose for any compound
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	20.00%
2021 PSU \| First patient enrolled in the expansion cohort of the Phase 1 ON123300 clinical trial
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	20.00%
2021 PSU \| First patient enrolled in a registrational study for any compound
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	20.00%
2021 PSU \| Topline data of a registrational study for any compound
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	20.00%
SAR awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share base amount (per share)		$ 8.40
Share Based Compensation Arrangement By Share Based Payment Award for Cash Payment Of Each SAR		13.20
Compensation expense					$ 442,000
Unrecognized compensation expense related to unvested stock options			$ 528,000		528,000
SAR awards \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share price (in dollars per share)		$ 21.60
2020 SAR
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock option grants		256,713
Share base amount (per share)		$ 8.40
Unrecognized compensation expense related to unvested stock options			$ 28,000		$ 28,000
2021 SAR
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)	67.00%				33.00%
Share base amount (per share)	$ 22.65
Shares issued			100,000		100,000
Unrecognized compensation expense related to unvested stock options			$ 350,000		$ 350,000
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares issued			104,700		104,700
Issue price (in dollars per share)			$ 5.19		$ 5.19
Compensation expense					$ 513,000
Vesting Percentage One \| 2020 PSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)		50.00%
Vesting Percentage One \| 2020 SAR
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)		33.00%
Vesting Percentage One \| Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)					33.00%
Vesting Percentage Two \| 2020 PSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)		50.00%
Vesting Percentage Two \| 2020 SAR
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)		67.00%
Vesting Percentage Two \| Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting (Percentage)					34.00%
Employee \| Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense					$ 30,000
Non employee directors \| SAR awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of awards issued		8,333
Non employee directors \| 2020 SAR
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock option grants		58,333

Research Agreements (Details)	9 Months Ended
Research Agreements (Details)	Sep. 30, 2021 USD ($)
License
Research Agreements
Revenue	$ 0

- Definition

Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 41
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9038-108599

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130545-203045

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 32
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8933-108599

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8906-108599

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8736-108599

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e8736-108599

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121604090&loc=SL49130543-203045

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 42
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9054-108599

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 40
-URI http://asc.fasb.org/extlink&oid=120311839&loc=d3e9031-108599

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 924
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 11.L)
-URI http://asc.fasb.org/extlink&oid=6472922&loc=d3e499488-122856

+ Details

Related-Party Transactions (Details) - Mount Sinai - USD ($)	3 Months Ended	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Related-Party Transactions
Payments to related party	$ 0	$ 0	$ 201,000
Amounts due to related party	$ 77,000	$ 77,000		$ 77,000

Securities Registrations and Sales Agreements - January 2020 Offering (Details) - USD ($)						1 Months Ended		3 Months Ended	9 Months Ended
	Sep. 28, 2021	Feb. 16, 2021	Jan. 11, 2021	Jul. 29, 2016	Jan. 05, 2016	Jan. 31, 2020	Dec. 31, 2019	Sep. 30, 2021	Sep. 30, 2021	Sep. 30, 2020
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)	5,000,000	1,916,667	1,303,408	16,000	861
Payment of Non-accountable Expenses							$ 85,000
Payment of Clearing Fees							$ 10,000
Number of securities to each class of warrant (in shares)					430
Securities purchase agreements
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)							1,844,168
Common Stock
Subsidiary, Sale of Stock [Line Items]
Issuance of common stock, net (in shares)								5,109,523	8,329,598	1,844,168
Non-tradable warrants with exercise price 2.00 Equity
Subsidiary, Sale of Stock [Line Items]
Warrant exercise price (in dollars per share)								$ 30.00	$ 30.00
HCW
Subsidiary, Sale of Stock [Line Items]
Warrant exercise price (in dollars per share)							$ 6.7785
Percentage of management fees on gross proceeds							7.00%
Proceeds from issuance of warrants						$ 9,000,000.0
HCW \| Maximum
Subsidiary, Sale of Stock [Line Items]
Number of securities to each class of warrant (in shares)							92,208
Certain institutional and accredited investors
Subsidiary, Sale of Stock [Line Items]
Percentage of management fees on gross proceeds							1.00%

Securities Registrations and Sales Agreements - 2021 Offering (Details) - USD ($)										1 Months Ended		9 Months Ended
	Sep. 28, 2021	Sep. 23, 2021	Aug. 20, 2021	Feb. 16, 2021	Feb. 10, 2021	Jan. 11, 2021	Jan. 07, 2021	Jul. 29, 2016	Jan. 05, 2016	Sep. 30, 2021	Dec. 31, 2019	Sep. 30, 2021	Sep. 30, 2020	Jul. 09, 2020
Aggregate shares issued	5,000,000			1,916,667		1,303,408		16,000	861
Share Price									$ 2,137.50					$ 21.60
Net proceeds	$ 19,500,000			$ 26,700,000		$ 8,500,000			$ 1,840,000			$ 55,091,000	$ 9,062,000
Securities purchase agreements
Aggregate shares issued											1,844,168
Offer price (per share)											$ 5.4225
Lincoln Park Capital Fund, LLC \| The Offering
Expense reimbursement												$ 100,000
Percentage rights to participate												50.00%
Threshold period for exercise or conversion of stock												one
Institutional Investors \| The Offering
Aggregate shares issued							1,303,408
Purchase price							$ 6.675
Net proceeds												$ 8,500,000
Guggenheim Securities, LLC \| The Offering
Aggregate shares issued		5,000,000
Share Price		$ 4.20
Underwriters option exercisable term		30 days
Net proceeds		$ 19,500,000
Cash fee		6.00%
Legal fees and expenses		$ 100,000
Guggenheim Securities, LLC \| Over-allotment
Aggregate shares issued					1,666,667
Purchase price					$ 15.00
Threshold period for exercise or conversion of stock					30
Net proceeds					$ 26,700,000
Additional shares agreed to issue					250,000
Cash fee					6.00%
Legal fees and expenses					$ 100,000
Piper Sandler & Co
Aggregate shares issued										109,523
Net proceeds										$ 0.5
Weighted average price per of common share										$ 5.32		$ 5.32
Piper Sandler & Co \| At the Market Equity
Aggregate shares issued										109,523
Net proceeds										$ 500,000
Percentage of gross proceeds of shares of common stock sold			3.00%
Weighted average price per of common share										$ 5.32		$ 5.32
Maximum \| SAR awards
Share Price														$ 21.60
Maximum \| Guggenheim Securities, LLC \| Over-allotment
Aggregate shares issued		750,000
Maximum \| Piper Sandler & Co \| At the Market Equity
Net proceeds			$ 25,000,000.0